Synthesis of the Furan Derivatives. XLI. : Reaction of 2-Furyl Bromomethyl Ketone, 5-Nitro-2-furyl Bromomethyl Ketone and 4-Bromophenacyl Bromide with Dimethyl Sulfoxide
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منابع مشابه
Furan derivatives. ЬХХП. Synthesis and some properties of l-(5-nitro-2-furyl)- -2- (5-aryl-2-furyl)ethylenes
Wittig reaction has recently been applied also in the preparation of 5-nitrofuran derivatives of ethylene [1—5]. The quoted syntheses were accomplished starting either from 5-nitrofurfuryl halides which were converted into 5-nitrofurfurylidenephosphoranes and subsequent condensation of the latter with carbonyl compounds [1—4], or the intermediate phosphoranes were prepared from other furfuryl h...
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Crystals of the title compound, C(12)H(10)N(4)O(5), were obtained from a condensation reaction of 2,4-dinitro-phenyl-hydrazine and 2-furyl methyl ketone. The mol-ecule displays a nearly planar structure, and the furan ring is slightly twisted by a dihedral angle of 12.62 (6)° with respect to the phenyl-hydrazone plane. The face-to-face separation of 3.287 (7) Å between parallel benzene rings of...
متن کاملBiotransformation of the Bladder Carcinogen JV-[4-(5-Nitro-2-furyl)-2- thiazolyl]formamide in Mice1
The biotransformation of A/-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT), a potent urinary bladder carcinogen, was studied in mice. About 82% of radioactivity was excreted as 14C02within 36 hr after intragastric administration of /V-[4-(5-nitro-2-furyl)-2thiazolyl]-[14C]formamide, suggesting its deformylation to 2amino-4-(5-nitro-2-furyl)thiazole (ANFT). The latter was formed in vitro as ...
متن کاملBiotransformation of the bladder carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in mice.
The biotransformation of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT), a potent urinary bladder carcinogen, was studied in mice. About 82% of radioactivity was excreted as 14CO2 within 36 hr after intragastric administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-[14C]formamide, suggesting its deformylation to 2-amino-4-(5-nitro-2-furyl)thiazole ( ANFT ). The latter was formed in vitro ...
متن کاملStatistical analysis on toxicity of a nitrofuran derivative, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide.
A food additive, furylfuramide or AF-2, which had been used in Japan since 1965 and structurally is composed of 5-nitro-2-furyl radical and acrylamide, was re-examined mainly on chronic toxicity by statistically reviewing published data. The conclusions are as follows: 1) The maximum safety dosage which shows no demonstrable change in rats must be corrected at least to 1/170 of the value which ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1968
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.88.10_1306